Engineered for Industrial Leaders in Pharma, Food, and Green Chemistry. 38 years of expertise ensure optimal performance for research and industrial applications.
Solve Your Toughest Extraction Challenges with Zero Compromise
Your separation and purification processes deserve innovation that works. Our Supercritical CO₂ Extraction System isn’t just equipment—it’s a profit multiplier for industries battling inconsistent yields, thermal degradation, or regulatory hurdles. Here’s why 100+ global clients trust us.
Supercritical CO₂-based extraction systems exhibit distinctive operational advantages through their employment of carbon dioxide as the solvent medium
Isolate bioactive compounds without damaging heat-sensitive ingredients. Targeted molecular selectivity through pressure-temperature optimization for specific compound isolation. Rapid mass transfer kinetics accelerating extraction efficiency
Slash solvent costs with CO₂ recycling and energy-efficient workflows. Repeatable, batch-to-batch precision. Gentle ambient-temperature processing ideal for thermolabile compounds, effectively preventing oxidative degradation and photochemical reactions while preserving natural flavor profiles
Broad operational adaptability with precise parameter modulation capabilities. Ecologically superior solvent characteristics – non-toxic, odorless, inert, non-flammable, economically viable, and fully recyclable.
Modular designs from 5 mL (R&D) to 30,000 L (industrial). Free lab./pilot testing + reactor/distillation designs tailored to your material kinetics. Integrated extraction-separation mechanism ensuring complete CO₂ phase transition without volatile residue retention.
high costs, scalability issues, process optimization, maintenance, and regulatory compliance
We’ve worked with 300+ clients—here’s how we fix what keeps you up at night:
Unlike generic solutions, our systems are custom-engineered for your material, process, and scale. We optimize reactor design (long-aspect ratios, mass-transfer structures) to match your extraction kinetics, ensuring peak efficiency.
Choose from modular designs for R&D (5 mL) to industrial-scale (39 L+) and customize media (CO₂, ethanol, propane) or processes (extraction, distillation, entrainer-assisted separation).
Operate at near-ambient temperatures to preserve delicate bioactive ingredients (e.g., herbal extracts, essential oils) and eliminate thermal degradation.
CO₂ is recyclable, non-flammable, and cost-effective. Reduce solvent expenses by up to 70% vs. traditional methods.
Achieve faster extraction cycles (minutes vs. hours) and seamless scale-up from lab to production.
Supercritical CO₂ extraction technology is not a “one-size-fits-all” solution.
It requires customization based on the type of material being processed and the specific extraction process.
Each system must be engineered to handle the unique dynamics of mass transfer within the reactor, depending on the material’s properties, composition, and state (solid or liquid).
Comprehensive professional advice and small-scale trials are available upon request.
High-quality, cost-effective supercritical fluid systems with custom design and
Optimal Value
Supercritical Fluid Extraction (SFE) systems are designed with operational training scenarios designed to help customers fully understand the system’s operating logic, critical control points and emergency response. These scenarios simulate real operations and potential problems to improve operator control of the system.
Tailored Reactor Designs: We engineer reactors based on your material’s mass transfer kinetics, porosity, and solvent interaction. No generic designs.
Modular Scalability: Start small (5 mL lab-scale) and scale to 29,000 L industrial systems. Pay as you grow.
Predictive Maintenance IoT: Real-time alerts for pressure leaks, pump wear, and CO₂ recovery efficiency drops.
24/7 Global Support: Avg. response time: 12 minutes.
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Optimized Parameters: Machine Process and Flow adjusts pressure/temperature in real time to slash cycle times by 30%.
Free Onsite Training: Includes process optimization workshops and troubleshooting manuals.
Supercritical extraction technology represents the most recent scientific discipline emerging in modern chemical separation processes, heralded globally as a sophisticated separation methodology. A supercritical fluid is defined as a substance existing in a thermodynamic state beyond its critical point (Pc, Tc) – the precise juncture where liquid-gas phase boundaries vanish. Supercritical carbon dioxide exhibits extraordinary physicochemical characteristics: its density approximates that of a liquid while maintaining gas-like viscosity, complemented by exceptional diffusion coefficients, low viscosity, and substantial dielectric constants. These distinctive properties render it an exceptional solvent with superior separation efficacy.
The supercritical extraction process operates through high-pressure infusion at optimized temperatures within extraction vessels, facilitating solute diffusion into the solvent matrix. Subsequent modulation of operational parameters in separation chambers induces selective solute precipitation, thereby achieving precise substance isolation.
System Configuration Overview
CO₂ Supply:
User-provided CO₂ cylinders (≥22 kg each, 99% purity, food-grade certified)
High-Pressure Pump System:
Variable-frequency plunger pump: 50 L/h @ 50 MPa (ceramic plunger, liquid-cooled pump head)
Co-Solvent Delivery:
Auxiliary pump: 4 L/h @ 50 MPa
Extraction Vessels:
Tandem extractors: 5L + 5L + 2L (50 MPa rated)
Thermal management: Jacketed heating with insulation, integrated feed hopper
Fractional Separation Array:
Primary separator: 2L @ 30 MPa
Secondary separator: 1L @ 30 MPa
Thermal regulation: Heated jackets with insulation
Cryogenic System:
Refrigeration unit with CO₂ condenser reservoir & helical heat exchanger
Thermal Control Infrastructure:
Five circulating water baths with shell-and-tube heat exchangers for vessels
Optional Instrumentation:
Precision pressure monitoring: Transducers with digital gauges
Process Automation:
PID temperature controllers with multi-channel display
Flow Metrology:
Mass flow meter with CO₂ volumetric monitoring
Optional HMI System:
Touchscreen PLC interface (pressure/temperature/flow data logging & print output)
Functional Capabilities:
(1) Automated flow regulation for CO₂/co-solvent pumps
(2) Dynamic temperature control for extraction/separation vessels
(3) Real-time pressure monitoring (reservoir/vessels/pump discharge)
(4) Data export via USB with customizable reporting formats
Fluid Handling System:
High-pressure tubing: DW6-series fittings with structural supports
Pre-Operational Preparations
Power Supply Verification
Confirm integrity of three-phase four-wire power supply (380V/50Hz or similar).
Cryogenic System Preparation
Charge refrigeration unit reservoir with 30% ethylene glycol/70% aqueous solution.
Connect cooling water lines to CO₂ pump head.
CO₂ Supply Conditioning
Maintain cylinder pressure at 5–6 MPa (apply electric heating band if ambient temperature <15°C).
System Integrity Check
Inspect all piping connections and fittings for proper sealing and mechanical stability.
Thermal Fluid Charging
Fill heating jackets with deionized water (maintain 2–3 cm headspace below fill port).
Feedstock Preparation Protocol
Mill botanical materials (seeds/roots/stems) to 20–60 mesh particle size.
Optimize moisture content to 5–10% (w/w).
Load extraction thimbles to 2–3 cm below filter screen.
For fine particulates: Install medium-flow filter paper beneath sintered metal frit to prevent particulate migration.
Extraction Vessel Assembly
Install charged thimble into extraction chamber.
Mount specified O-ring (P/N: _____) on thimble flange.
Assemble gas distribution ring and secure with compression gland (using designated high-pressure O-ring: P/N _____).
Co-Solvent System Setup
Charge modifier reservoir when processing polar compounds (enhances CO₂ solvation power through polarity modification).
Critical Notes:
All sealing elements must meet ASME BPE-2019 standards for high-pressure service.
Maintain positive displacement pump cooling circuit flow >3 L/min during operation.
For thermolabile compounds, implement pre-chilling of CO₂ feed line to ≤10°C.
Pressure Regulation:
Note: For prolonged shutdowns, reset Valve 12 to default open position.
Critical Reminders:
(Operational parameters assume standard botanical feedstock; adjust for specialty applications.)
Authorized personnel only – Operation restricted to trained technicians.
Constant supervision required during pressurized operation.
Emergency protocol: Immediate shutdown and power disconnection upon abnormalities.
Refer to manufacturer’s manual for detailed procedures.
Consult equipment-specific maintenance manuals.
(1) Pump Cooling Verification
Confirm active coolant circulation (supplied by chiller) during CO₂ pump operation.
(2) Pressurization Protocol
Initiate CO₂ pressurization only after chiller reaches setpoint temperature (4°C).
Purge air via pump outlet vent valve prior to pressurization.
(3) Ice Clogging Mitigation
Symptoms: Low storage tank pressure (vs. CO₂ source/Separator II), flow obstruction.
Root Cause: Moisture ingress (CO₂/feedstock).
Solutions:
A. Regularly drain water from purifier base valve.
B. Maintain feedstock moisture ≤10%.
C. Ice Removal Procedure:
Open chiller cover → Power off.
Allow gradual warming to ambient temperature.
Vent CO₂/water slowly → Purge system with dry N₂.
(1) Power Supply Validation
Verify correct 3-phase wiring before startup – No-phase operation prohibited.
(2) Thermal Fluid Maintenance
Daily/Shift Check:
Replenish deionized water in heating jackets (combat evaporation).
Inspect circulation pump for:
Motor operation (prevent seizure from scale buildup).
Shaft mobility (critical after prolonged downtime).
Consequence of Neglect:
Dry heating → Element burnout.
Pump failure → Motor damage.
Proactive Measures:
Implement weekly descaling for hard water areas.
Install low-level cutoff sensors for automated protection.
*(All procedures assume food-grade CO₂ (99.9% purity) and ambient humidity <60%. Adjust for extreme conditions.)*
Consultation & Pilot Testing
Free material analysis and small-scale trials to identify optimal pressure, temperature, and solvent blends. Example: A nutraceutical client reduced extraction time from 8 hrs to 2.5 hrs after we tested 12 entrainer ratios.
Reactor Design Engineering
Customize reactor geometry (long-aspect ratios, baffle structures) to match your material’s diffusivity and solubility.
Process Integration
Seamlessly integrate with your existing workflows (e.g., inline HPLC for purity checks, automated CO₂ recovery loops).
We will contact you within two working days, please pay attention to the email with the suffix”@greatwallcontrol.com”
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